Life Science Research Professional 2
Company: Stanford Medicine
Posted on: January 10, 2022
The Department of Genetics at Stanford University is seeking an
experimental research associate (Life Science Research Professional
2) to join the Jerby Laboratory to study the underlying principles
and molecular underpinnings of multicellular dynamics in cancer.
The ideal candidate will join the team as soon as possible.
Lab overview: Immune responses and tissue homeostasis rely on
highly orchestrated multicellular regulation, where different cell
types and the interactions between them can either halt or promote
pathological processes. Grasping the logic of multicellular
dynamics is fundamental to our understanding of many biological
processes, and can greatly advance our ability to detect, treat,
and even prevent, a wide range of diseases, including cancer. As
such circuits consist of an immense number of interacting
components, which often function in a context-dependent manner, our
ability to decipher and target them is still very limited.
The Jerby lab, which launched very recently at Stanford University,
develops integrative, multidisciplinary approaches to track, model,
and perturb multicellular dynamics at scale, focusing on the
cancer-immune interplay. Combining single-cell technologies with
genetic editing and machine learning, we aim to unravel the causal
structure of multifactorial immune evasion mechanisms in highly
aggressive tumors, develop new ways to trigger and augment targeted
anti-tumor immune responses, and provide a blueprint for the study
of multicellular (dys)regulation in health and disease. For more
information about our research and laboratory, see
Job description: We are looking for enthusiastic and creative
people, for one of several roles, including: lab manager, senior
research scientists, and research associates. Candidates are
expected to lead and design experimental projects to tackle key
questions and challenges in cancer immunology. Specific projects
include developing a multimodal perturb-seq system to identify key
regulators of cancer-T-cell interactions; mapping cancer-immune
dynamics across time and space using emerging single-cell and
spatial profiling technologies; and integrating genetic and
environmental editing to decipher combinatorial effects driving
multifactorial immune evasion mechanisms.
The candidate should have experience with molecular and cell
biology techniques, primary cell culture, and ideally also single
cell sequencing and/or genetic editing; high level of initiative
and motivation; ability to work independently and with a team;
excellent communication, organization, and time management skills;
creative thinking and passion for science.
The Jerby lab is a supportive and interdisciplinary workplace that
provides exposure to innovative research and cutting-edge
technologies. This position is a unique opportunity for scientific
growth and development with the potential for widespread
recognition of scientific contributions.
To apply, please also email Dr. Jerby at firstname.lastname@example.org.
- Design research approaches for a major portion of research
project(s), including background research, experimental design and
execution, problem-solving, and writing up for publication.
- Develop new protocols; test, evaluate, and optimize a variety
of approaches, including single-cell RNA-Seq, spatial sequencing,
ex-vivo co-culture experiments, and genetic/pharmacological
perturbations with sequencing- and image-based readouts.
- Perform complex experiments, and maintain detailed records of
experiments and outcomes; analyze and interpret research data
resulting from original procedures and methods.
- Help supervise and train new staff or students as needed,
including interviewing, hiring, performance management, and related
duties; provide laboratory orientations and day-to-day guidance to
support trainees and assist them in troubleshooting and optimizing
their protocol and experimental workflows.
- Maintain the lab infrastructure and equipment; oversee and
maintain lab stocks of common reagents; coordinate the ordering and
shipment of equipment, maintain a database to manage these orders,
and ensure orders are placed and delivered in a timely manner.
- Work with health and safety department to ensure lab complies
with regulations and all required trainings; serve as the
laboratory safety officer to ensure safe work practices as dictated
by Environment, Health & Safety (EH&S) guidelines; develop and
update the Standard Operating Procedures (SOPs) and protocols.
- Proficient in molecular and cell biology, with hands-on
experience in tissue culture methods and the operation of standard
- Experience in single-cell RNA-Seq of tissues (e.g., tissue
dissociation, cell sorting, library construction and
next-generation sequencing), and/or spatial sequencing
- Strong core competencies in a variety of cell and molecular
biology techniques, including, for example, flow cytometry, cell
sorting, live cell imaging, reporter systems, CRISPR-based genetic
editing, and experience with primary human T cell (e.g., activation
assays) and primary cancer cell cultures.
- Prior experience and expertise required to perform, optimized,
and quickly master the procedures described above, and then
effectively disseminate their knowledge and train other lab
- Exceptional organizational, time management and critical
- Excellent lab notebook practices and attention to details.
- Excellent communication skills; will and ability to interact
with all levels of staff, external contacts, students, trainees,
- Enthusiasm, curiosity, and eagerness to learn and develop,
collaborate and contribute to an inclusive and supportive
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and two years of
relevant work experience; or Master's degree in a related
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
- Comprehensive understanding of scientific principles.
- General computer skills and ability to quickly learn and master
computer programs, databases, and scientific applications.
- Strong analytical skills and excellent judgment.
- Ability to maintain detailed records of experiments and
- Ability to work under deadlines with general guidance is
- Excellent organizational skills and demonstrated ability to
accurately complete detailed work.
- Frequently stand, walk, twist, bend, stoop, squat, grasp
lightly, use fine manipulation, grasp forcefully, perform
desk-based computer tasks, use telephone, write by hand, lift,
carry, push and pull objects weighing over 40 pounds.
- Occasionally sit, kneel, crawl, reach and work above shoulders,
sort and file paperwork or parts.
- Rarely climb, scrub, sweep, mop, chop and mix or operate hand
and foot controls.
- Must have correctible vision to perform duties of the job.
- Ability to bend, squat, kneel, stand, reach above shoulder
level, and move on hard surfaces for up to eight hours.
- Ability to lift heavy objects weighing up to 50 pounds.
- Ability to work in a dusty, dirty, and odorous
- Position may require repetitive motion.
*- Consistent with its obligations under the law, the University
will provide reasonable accommodation to any employee with a
disability who requires accommodation to perform the essential
functions of his or her job.
- May require working in close proximity to blood borne
- May require work in an environment where animals are used for
teaching and research.
- Position may at times require the employee to work with or be
in areas where hazardous materials and/or infectious diseases are
- Employee must perform tasks that require the use of personal
protective equipment, such as safety glasses and shoes, protective
clothing and gloves, and possibly a respirator.
- May require extended or unusual work hours based on research
requirements and business needs.
WORK STANDARDS (from JDL):
- Interpersonal Skills: Demonstrates the ability to work well
with Stanford colleagues and clients and with external
- Promote Culture of Safety: Demonstrates commitment to personal
responsibility and value for safety; communicates safety concerns;
uses and promotes safe behaviors bases on training and lessons
- Subject to and expected to comply with all applicable
University policies and procedures, including but not limited to
the personnel policies and other policies found in the University's
Administrative Guide, http://adminguide.stanford.edu .
- Schedule: Full-time
- Job Code: 4952
- Employee Status: Regular
- Pay Grade: G
- Department URL: http://genetics.stanford.edu/
- Requisition ID: 87433 As an organization that receives federal
funding, Stanford University has a COVID-19 vaccination requirement
that will apply to all university employees, including those
working remotely in the United States and applicable
subcontractors. To learn more about COVID policies and guidelines
for Stanford University Staff, please visit
Keywords: Stanford Medicine, Richmond , Life Science Research Professional 2, Other , Richmond, California
Didn't find what you're looking for? Search again!